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Groups of primates (Macaca arctoides) were fed either a control (n=4) or a high-cholesterol diet (n=4) for a period of at least five years. Serum cholesterol levels in the experimental group were in excess of 250 mg/dl while the control group had levels from 150 to 200 mg/dl. In-111-labeled platelets and Tc-99m-labeled red blood cells were injected into each animal, and consecutive images were taken and stored in a computer immediately thereafter and 24 hours later. The Tc-99m-labeled red blood cell image was used to subtract the blood pool background from the In-lll-labeled platelet image to enhance visualization of platelet deposition. The subtracted images allowed the platelet deposition in the regions of the abdominal aorta, femoral, carotid, and renal arteries to be determined. All of the experimental monkeys hafi abnormal accumulation versus only one of the control animals. Four of the animal studies were repeated (2 experimental and 2 control), and comparable results were obtained. The animals were then given 3 mg/kg/day of aspirin for 5 days and the studies repeated. No abnormal accumulations of platelets were seen in the animals after treatment with low-dose aspirin (30 mg/kg/day) and prostacyclin (PGI2). Our results suggest that In-lll-labeled platelets may be useful to study the pathogenesis of arteriosclerosis and pharmacological techniques for its amelioration.

Use Of Indium-111 Labeled Platelets To Assess Platelet Deposition On Arteriosclerotic Plaques In A Primate Model