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5 normolipemic minipigs treated daily for 28 days with 40µg/kg h-calcitonin synthetized in thoracic (4,0±0,8 pgPGI2/mg/min) and abdominal (3,2±0,7 pg) aorta significantly more prostacyclin than in 5 control animal^ receiving the vehicle only (3,4 ± 0,6 pg and 2,3±0,7 pg) respectively. In 8 healthy males aged 26-32 years, a single intramuscular injection of 0,5 mg calcitonin led to an increase and measurable levels of 6-oxo-PGF1α (about 100pg/ ml) between 15 and 30 minutes after application (lower detection limit: 70 pg/ml). Calcitonin levels after 5 minutes increased to more than 1000pg/ ml and started to decline after 60-120 minutes. In two healthy volunteers (physicians) 30 minutes after i.m. application of 0,5 mg calcitonin, PGI2- formation in the forearm vein was examined by the bioassay technique of Moncada. The values after calcitonin application (x = 9,86 pg) were found to be enhanced in comparison to age and sex matched controls (x = 7,11 pg). The same 8 healthy males received also a depot-calcitonin and salmon-calcitonin (100 MRC-units), and the time course of 6- oxo-PGF.x in unextracted plasma and caltitonin was was estimated. In 50 patients with peripheral vascular disease, after a single calcitonin administration,the 6-oxo-PGF1αlevels remained under the level of detection. 11: is discussed, whether the temporarily enhanced vascular PGI2-synthesis as well as the increase of 6-oxo-PGF1α-levels could be an explanation for the beneficial role of calcitonin seen in the treatment of this disease.

Increased Vascular PGI2-Formation And Increased Plasma 6-OXO-PGI1α After Calcitonin In Human And Experimental Animals