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Ninety-five patients with acute deep venous thrombosis (DVT) in the leg were randomly allocated to either two daily subcutaneous injections (S.C.) or to continuous intravenous infusion (I.V.) of heparin for at least five days. Before entering the trial the existence of a thrombus was confirmed with phlebography and in about two thirds pletysmography and thermography (DevethermR, infrared temperature scanning) was performed at well. Immediately after heparin treatment phlebography was repeated in one third of the patients and in the others a new pletysmography and thermography was performed. The non-invasive procedures are then repeated again after 1, 3, 6 and 12 months (and once a year). In most patients the thrombi were localized in the popliteal-femoral veins and all patients had local symptoms. The amount of heparin required to maintain a prolongation of the APT-time 1 1/2 to 3 1/2 times was the same in both groups and the daily dosages varied between 25.000 and 50.000 units. In two patients, one of whom on salicylates the S.C. administration was stopped due to local haematoma. Major bleeding complications occurred in totally 4 patients, two on heparin I.V. By phlebography a partial thrombolysis was registered in about 25% of the patients after heparin treatment independent of administration route, and in no patient the thrombus progressed in size. By pletysmography and thermography an improvement was demonstrated in about one third immediately after heparin treatment and these improvements were not less pronounced in the S.C. group. Only one major, non-fatal pulmonary embolus (heparin I.V.) occurred.  Thus, S.C. administration of heparin seems to be as efficient and safe as administration of heparin I.V. in the treatment of patients with acute DVT.

Subcutaneous Versus Intravenous Administration Of Heparin In The Treatment Of Acute Venous Thrombosis