English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The template bleeding time is used extensively for measurements of in vivo platelet function in thrombocytopenic patients and for evaluations of platelet transfusions. Interpretation of results is complicated by technical difficulties of the test procedure and by patient symptoms including sepsis, fever, splenomegaly, alloimmunization and drug therapy. In an attempt to find additional tests which predict function of circulating platelets, ex vivo measurements of platelet reactivity to vessel wall subendothelium, and template bleeding time tests, were performed on normal individuals and a series of hospital patients. Platelet reactivity in controls was 7.2 ± 3.3 um (n=10) and bleeding times were 3.1 ± 0.3 min. Reactivity decreased to 2.6 ± 0.6 um and bleeding times increased to 7.6 ± 3.6 min. in aspirinated controls (n=12). Patients with thrombocytopenia and prolonged bleeding times (n=15) consistently gave reduced reactivity values. Thus, the direct, inverse relationship between in vivo function (bleeding time) and ex vivo function (platelet reactivity) support the idea that the laboratory test is a valid measurement of platelet capabilities for function in vivo. Unlike bleeding time tests, ex vivo measurements of reactivity can be performed apart from patient symptoms which complicate measurement of function in vivo and under controlled conditions.

An Ex Vivo Test Of Platelet Function Correlates With Template Bleeding Times And Is Unaffected By Symptoms Of Patients With Thrombocytopenia