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There is good evidence that internal surfacing of vascular prostheses by a non-thrombogenic biological layer is important for satisfactory long-term clinical results. However morphological and histological data obtained so far on the so called neo-intima provide little information about the anti-thrombogenic activity of the newly formed endothelium.  In order to characterize the functional activity of the neo-intima we have developed a device to measure prostacyclin (PGI2) release from the vascular wall into the lumen. Different types of vascular grafts (velour knitted dacron, P.T.F.E. length 10cm, diameter 4-6mm) were placed in the carotid arteries of sheep. After removal the grafts were cut in three transverse sections (proximal, medial and distal third) and were subsequently perfused with oxygenated buffer in order to restimulate the arachidonic acid metabolism in the newly formed vascular wall. Thereafter the sections were filled with a specific volume of buffer and incubated. In the incubated solution PGI2 release was measured using a collagen and ADP induced platelet aggregation model and a 6-Keto- PGF lalpha radioimmunoassay.  Within four months postoperatively PGI2 release increased especially in the proximal and distal sections of the prostheses up to the normal range, while in the medial sections of some grafts even 6 months postoperatively the PGI2 release remained weak. Simultaneous investigations obtained by scanning electron microscopy revealed that there is no clear correlation between the morphology of the newly formed endothelium lining different types of vascular prostheses and the functional activity of the neo-intima. This makes it desirable to characterize the functional activity of the neointima with regard to the non-thrombogenicity of the newly formed endothelium. Improvements in newly developed vascular prostheses can thus be quantitatively measured.

Prostacyclin Release In Vascular Prostheses With Regard To The Non-Thrombogenicity Of The Neo-Intima