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The influence of aspirin on the fibrinolytic and renin systems was studied in 10 healthy young men, who served as their own controls. Basal blood samples were obtained after a 15-minute rest, immediately after exercise, and following a 15-min post-exercise rest. Later, (7-14 days) 1250 mg aspirin was ingested 1 hr. before test samples were obtained, as before. Exercise on a bicycle ergometer induced doubling of the resting heart rate within 2 min., and was continued for 3 min. longer. Aspirin induced a significant reduction in the level of plasminogen activator, before and after exercise, and also some decrease in hemoglobin and hematocrit levels. Exercise almost doubled the baspl plasma renin activity (PRA, angiotensin I, ng/ml plasma/hr., by radioimmunoassay) in the control and aspirin experiments. Aspirin did not significantly blunt this exercise-induced rise in PRA. However, after 15-minute rest, the control PRA remained elevated, while the postaspirin PRA was 37% below it (p &lt; 0.025). After cold activation of the plasmas (-4°C, 72 hr.), the PRA increment over corresponding non-activated samples was used to estimate “prorenin”. Prorenin as % of active renin before aspirin was 347.2, 210.5, and 210.8, for the basal and 2 post-exercise periods respectively; after aspirin the values were 460.5, 354.9, and 353.4. Clearly, exercise depresses the proportion of prorenin, suggesting an exercise-induced enhancement of prorenin conversion, possibly related to the exercise-induced stimulation of the fibrinolytic system. After aspirin, all 3 prorenin percentages are higher, implying that it interferes with prorenin conversion. Thus, exercise increases both fibrinolysis and PRA. The increase in PRA could be due in part to fibrinolytic enzyme conversion of prorenin (plasmin activates prorenin in vitro). Aspirin suppresses plasminogen activator, and thus prorenin activation.

Suppression Of Exercise-Induced Plasminogen Activator And Plasma Renin Activity Following Aspirin Ingestion