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The rate of destruction of autologous 51Cr-labeled blood platelets has been measured in baboons having femoral arteriovenous shunts composed of various test materials. Platelet survival was normal in baboons with chronic Teflon-Silastic shunts alone demonstrating that the surgical variables had no detectable effect. Platelet survival data obtained when other materials were studied were analyzed by computer modeling to estimate both the rate of shunt-associated platelet destruction and the rate of platelet removal by ordinary senescent mechanisms. Rates of shunt associated platelet destruction, normalized with respect to shunt surface area (plats/cm2 -day), were used to assess material thrombogenicity. Polymers studied included poly(ethyl methacrylate) (EMA), poly(hydroxyethyl methacrylate) (HEMA) and two intermediate copolymers (HEMA/EMA: 1/1, 1/3) radiation grafted onto two substrates (silastic and polyethylene). Og both substrates rates of platelet consumption (range:	5-20 × 108 plats/cm2 -day) correlated with:	I) HEMA/EMA monomer ratios; 2) graft polymer water absorption measurements; and 3) surface ratios of carbon to oxygen atoms and of various functional groups as determined from electron spectroscopy for chemical analysis (ESCA). With ten commercial polyurethane materials rates of platelet consumption (range: 2-23 × 108 plats/cm2 -day) correlated inversely with the percentage of surface carbon atoms forming hydrocarbon bonds, and directly with the surface content of ether-type linkages (which will be related to polyether “soft” segments) as determined from ESCA.  These observations in primates indicate that the thrombo- genecity of prosthetic materials is strongly influenced by their surface physicochemical properties.

Correlations Between Platelet Consumption And The Surface Chemistry Of Neutral Polymers In Baboons