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Recovery of platelet and endothelial prostaglandin synthetic activity by membrane cyclooxygenase after aspirin suppression of the enzyme is relevant to attempts to influence these pathways in platelet and microvascular disorders. Recovery from platelet inhibition has previously been measured by a colorimetric technique and proposed as a method for measurement of platelet turnover. Indirect methods have been used to determine prostacyclin production after similar inhibition and have not clarified the precise recovery rates. In the present study recovery in human and rat platelets was measured using a radioimmunoassay (RIA) for thromboxane B2 (TXB2) and in rat aortic endothelium with a RIA for 6-keto-prostaglandin- F1α (6KPGF1α).  TXB2 was measured in human platelet rich plasma stimulated with collagen and arachidonic acid before and after ingestion of 900 mg of aspirin. TXB2 returned to preaspirin levels in 8.5 ± 0.6 (S.D.) and 8.25 ± 0.5 days respectively with collagen and arachidonic acid, the recovery corresponding with platelet survival time of 51Cr autologous platelets. The recovery curve was linear with collagen but not with arachidonic acid where a late rise occurred.  Rats were treated with a single dose of aspirin 20 or 100 mg/kg and sacrificed at intervals for measurement of collagen stimulated platelet TXB2 aortic endothelial 6KPGF1α- Recovery of both of these products was linear and reached pretreatment levels after 120 hrs in platelets and 48 hrs in endothelium after 20 mgAg but 100 mg/kg delayed endothelial recovery to 96 hrs.  These results indicate that the endothelial and platelet enzyme are equally susceptible to aspirin but endothelial recovery is more rapid at low doses. Collagen stimulated platelet recovery may prove a useful method for measuring platelet production.

Recovery Of Platelet And Endothelial Cyclooxygenase After Aspirin Measured By Radioimmunoassay For Thromboxane B2 And 6-Keto-Pg-F1α