English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

It has been postulated that fibrin deposition is controlled by the relative competition of thrombin and plasmin for fibrin I. We have tested this hypothesis by measuring haemostatic activation products in the plasma of patients undergoing hip replacement. Thrombin sensitive fragment fibrinopeptide A (FpA), plasmin sensitive fragment Bβ1-42 and β thromboglobulin (βTG) have been measured before and after operation (n=26). The incidence of venous thrombosis was assessed by phlebography and I125 fibrinogen scanning. The mean preoperative FpA, Bβ1-42 and βTG concentrations were 1.80, 4.22 and 0.99 pmol/ml respectively. The mean FpA and βTG levels rose to 3.07 and 1.56 pmol/ml respectively on the sixth day after operation but the mean Bβ1-42 level rose more rapidly to a maximum of 10.9 pmol/ml on the fourth day after operation. In those patients who developed a thrombosis (n=9), the mean FpA level was higher on the first day after operation (2.83 pmol/ml) than in those patients (n=17) in whom thrombosis did not occur (1.66 pmol/ml). Conversly, the mean Bβ1-42 level was lower (4.76 pmol/ml) in those who developed a thrombus than in those without thrombus (6.79 pmol/ml). When the postoperative day 1 results were expressed as a ratio of FpA/Bβ1-42, the corresponding mean values of this ratio for the two groups of patients were 0.74 and 0.37. These results demonstrate that (a) there is an activation of the coagulation and fibrinolytic systems, and of platelets following hip replacement surgery (b) thrombus formation following major surgery is characterised by an increased action of thrombin on fibrinogen and a reduced action of plasmin on either fibrinogen or fibrin I (c) assays for FpA and Bβ1-42 may be useful for the detection of developing thrombi.

Relationship Between Fibrinogen Proteolysis, Platelet Release And Fibrin Deposition Following Total Hip Replacement