English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Significance: Chemically modified unnatural peptides are often endowed with improved biological and pharmacokinetic properties and are therefore valuable in the drug-discovery process. Modification by silicon-containing groups appears to be promising, because the presence of a silicon moiety in amino acids or peptides can help to improve permeation through membranes and increase proteolytic stability. Comment: Shi and co-workers have developed an efficient procedure for the synthesis of various -silyl--amino acids and oligopeptides by palladium(II)-catalyzed -C(sp3)–H silylation. The present site-specific late-stage C(sp3)–H functionalization is assisted by a picolinamide auxiliary and uses cheap and commercially available hexamethyldisilane as a silylating agent. Compatibility with a broad range of amino acid residues and the facile removal of the picolinamide auxiliary are noteworthy features of the present protocol. R

Palladium-Catalyzed Site-Selective γ-C(sp3)–H Silylation of Peptides