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A metal-free remote oxytosylation of 8-amidoquinolines has been achieved using Koser’s reagent to produce 5-tosyloxy-8-amidoquinolines in good yields. This method is compatible with various functional groups present on the aromatic ring.

Direct Oxytosylation of 8-Amidoquinolines by Koser’s Reagent: An Efficient Strategy for 5-Substituted 8-Amidoquinolines