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An efficient, simple protocol has been established for convenient synthesis of novel 2,3-disubstituted thieno[2,3- d ]pyrimidin-4(3 H )-one derivatives in good to high yields through a one-pot, two-step and three-component reaction from 2 H -thieno[2,3- d ][1,3]oxazine-2,4(1 H )-diones, aromatic aldehydes, and amines.

synopen

A Convenient One-pot Synthesis of 2,3-Disubstituted Thieno[2,3-d]pyrimidin-4(3H)-ones from 2H-Thieno[2,3-d][1,3]oxazine-2,4(1H)-diones, Aromatic Aldehydes and Amines