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A new variant of the Strecker synthesis using no-carrier-added [ 11 C]cyanide for the synthesis of radiolabeled amino acids is described. The protocol is fully automated using a radiochemistry synthesis module and applied to the production of a number of new PET radiotracers. [ 11 C- Carbonyl ]sarcosine, [ 11 C- carbonyl ]methionine, [ 11 C- carbonyl ]- N -phenylglycine, and [ 11 C- carbonyl ]glycine are all synthesized in moderate to good radiochemical yields. The synthesis of [ 11 C- carbonyl ]sarcosine has been validated for production of doses for clinical use, and preliminary evaluation of the new radiotracer in PC3 tumor-bearing mice is also reported.

High-Yielding Automated Convergent Synthesis of No-Carrier-Added [11C-Carbonyl]-Labeled Amino Acids Using the Strecker Reaction