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Indole, denominated by some authors as The Lord of the Rings of heterocyclic compounds due to its importance in fields like chemistry, biology, and medicine, represents the structural core of many natural and non-natural products with a wide range of biological properties, including antiviral and anticancer activities. An example of this spectrum of utilities is Arbidol, which is administered as a drug in Russia and China against influenza and other respiratory viral infections. Recent examples of other applications of indole-containing compounds are their potential use in SPECT imaging or detecting Aβ plaques in Alzheimer’s disease, as compound 3, or their use as ligands in the synthesis of organometallic complexes with optoelectronic properties and with potential use in the construction of light-emitting devices.Peer Reviewe

Indole, a Privileged Structural Core Motif