Open AccessIntradiscal Delivery of Mesenchymal Stem Cells in Collagen Microspheres in a Rabbit Disk Degeneration Model: A Preliminary Study
Author(s) -
Y. Y. Li,
Hao Diao,
ST Chow,
Vyl Leung,
Kmc Cheung,
BP Chan
Publication year - 2012
Publication title -
global spine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.398
H-Index - 26
eISSN - 2192-5690
pISSN - 2192-5682
DOI - 10.1055/s-0032-1319982
Subject(s) - mesenchymal stem cell , extracellular matrix , biomedical engineering , regeneration (biology) , intervertebral disc , medicine , tissue engineering , stem cell , saline , pathology , anatomy , microbiology and biotechnology , biology , endocrinology
Degeneration of intervertebral disk (IVD) has been characterized by the breakdown of the extracellular matrix and loss of water content and proteoglycan. Mesenchymal stem cells (MSCs) have been demonstrated as a promising cell source in disk regeneration. Injectable biomaterials as MSCs carriers allow needle-guided graft delivery to minimize trauma of the disc, and thus are preferable for IVD engineering. Our lab has developed a microencapsulation platform to make injectable solid microspheres entrapping cells in fiber meshwork of different extracellular matrices for scaffolding or cell delivery. As a first attempt, this study aims to compare the efficacy of injecting MSCs entrapped in collagen micro...link_to_OA_fulltex
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