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A simple and efficient procedure for the construction of 6,6a-dihydroisoindolo[2,1- a ]quinazoline-5,11-dione and 5-phenylisoindolo[2,1- a ]quinazolin-11(6a H )-one derivatives in acetic acid under catalyst-free conditions is described. Attractive features of this methodology are its versatility, ready availability of starting materials and the efficiency in creating a complex core in a single operation.

synlett

Studies on Novel Synthetic Methodologies, Part XII: An Efficient One-Pot Access to 6,6a-Dihydroisoindolo[2,1-a]quinazoline-5,11-diones and 5-Phenylisoindolo[2,1-a]quinazolin-11(6aH)-ones