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Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are widely accepted treatments for early colorectal neoplasms, but complications such as bleeding or perforation are often encountered, especially when the lesions being resected are large in size [1,2]. The closure of the mucosal defect reduces the risk of these complications [3,4]. Here, we report an effective technique involving the use of a standard endoscope and hemoclips to close a large mucosal defect after endoscopic resection. The procedure is carried out in two steps. First, to shrink the mucosal defect from the edges we apply an initial set of hemoclips (HX-610-090L, Olympus Medical Systems, Tokyo, Japan) to the submucosal layer of the center of the ulcer floor along the long axis of the ulcer (●" Fig.1,●" Fig.2, ●" Fig.3). Second, we apply additional hemoclips to the mucosal layer in the spaces left intentionally between the hemoclips applied in the previous shrinking stage of the procedure (●" Fig.4). The mucosal defect is thus closed completely with a total of 10 hemoclips (●" Fig.3c and●" Fig.5).●" Fig.6 shows the clinical case at 3 months after ESD: the mucosal defect had healed completely and all hemoclips had dropped off. Our technique is safe and easy to carry out and no special devices are required. It may be used in not only the colorectum but also potentially the stomach. It cannot be used in the esophagus because of the lack of a serous membrane in this region and in the duodenum as the duodenal muscle is very thin. This technique is based on the method of double-layered suturing of the surgical field following endoscopic closure. We have successfully used the novel method five times in our unit for defects with a mean size of 40mm. We conclude that this technique is an easy and effective method for complete closure of large mucosal defects after endoscopic resection.

endoscopy

Endoscopic double-layered suturing: a novel technique for closure of large mucosal defects after endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD)