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dle aspiration (EUS-FNA) is an established technique for diagnosis and staging of gastrointestinal malignancies. In a recent meta-analysis, the specificity and sensitivity of the procedure in assessing mediastinal lymph nodes have been calculated to be 96% and 88%, respectively [1]. We report upon a 47-year-old man with well-differentiated mucosal adenocarcinoma developed within a Barrett’s esophagus. During clinical work-up a hypoechoic periesophageal lymph node, measuring 13 mm in diameter, was detected by endoscopic ultrasound, and EUS-FNA was performed (l" Fig. 1 a). Cytology revealed neoplastic epithelial cells (l" Fig. 1 b) with marked aneuploidy according to DNA cytometry (l" Fig. 1 c), thus prompting esophagectomy with mediastinal lymph node dissection. The resection specimen confirmed the diagnosis of Barrett’s adenocarcinoma confined to the mucosa. All the resected lymph nodes, however, were free of cancer despite extensive work-up including stepwise sectioning and immunohistochemical investigation. The Barrett’s adenocarcinoma showed marked DNA aneuploidy with the same stemline ploidy values as those found in the FNA smears (l" Fig. 1 d). Contaminating normal cells are a common finding in EUS-FNA specimens, depending on the site from which the targeted lesion is approached [2]. Welldocumented reports on cases with falsepositive EUS-FNA due to transtumoral puncture are, however, exceedingly rare. In a case similar to ours, Peng et al. [3] recently reported upon an esophageal squamous cell carcinoma patient with a cytologically suspicious lymph node on EUSFNA in whom all the lymph nodes were negative in subsequent surgical node staging and resection. On slide review, some moderately atypical squamous cells were identified which most likely represented luminal contaminants from dysplastic squamous epithelium. To our knowledge, our case is the first to show false-positive EUS-FNA cytology of a mediastinal lymph node in a patient with Barrett’s esophagus, putatively owing to mucosal adenocarcinoma at the puncture site. Awareness of this diagnostic pitfall in the endoscopic community may help to avoid misinterpretation with possible severe clinical consequences.

endoscopy

False-positive mediastinal lymph node cytology due to translesional endoscopic ultrasound-guided fine-needle aspiration in a patient with Barrett’s early cancer