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The aim of the study was to evaluate the effects of thyroperoxidase antibody(TPOAb) and thyroglobulin antibody (TgAb) on maternal and neonatal adverseoutcomes in pregnant women. A total of 296 singleton pregnant women wereclassified into four groups according to the thyroid auto-antibody in the firsttrimester. Finally, there were 97 women in TPOAb positive group(TPOAb+/TgAb–), 35 in TgAb positive group(TPOAb–/TgAb+), 85 in TPOAb and TgAb positive group(TPOAb+/TgAb+), and 79 in TPOAb and TgAb negative group(TPOAb–/TgAb–). Thyroid function, TPOAb, and TgAb werechecked during pregnancy and followed up at 6 weeks, 3 months, 6 months, 9months, and 12 months postpartum. Levothyroxine sodium tablets could be taken tomaintain euthyroid antepartum. Thyroid function of women with postpartumthyroiditis (PPT) were followed up at 2 and 3 years postpartum. We observed theincidence of PPT, premature rupture of membranes (PROM), placental abruption,placenta previa, polyhydramnios, oligohydramnios, postpartum hemorrhage, pretermbirth, and low birth Weight in the four groups. 19.93% of the women hadPPT. The incidence of PPT in TPOAb+/TgAb–,TPOAb–/TgAb+, TPOAb+/TgAb+groupswas significantly higher than that in TPOAb–/TgAb–group, respectively (16.49 vs. 6.33%, 22.86 vs. 6.33%, 35.29 vs.6.33%, p &lt;0.05). The incidence of PPT inTPOAb+/TgAb+group was significantly higher than that inTPOAb+/TgAb– group (35.29 vs. 16.49%, p&lt;0.01). PPT occurred as early as 6 weeks postpartum, but mainly at 3 and6 months postpartum in the four groups (62.50%, 75.00%,70.00%, 80.00%). All PPT in TPOAb–/TgAb–group occurred within 6 months postpartum, while it was found at 9 months or 12months postpartum in other three groups. There was no classical form of PPT inTPOAb–/TgAb– group, while in the other three groups, allthree types (classical form, isolated thyrotoxicosis, isolated hypothyroidism)existed. At 2 years postpartum of the women with PPT, the rate of euthyroidismin TPOAb+/TgAb+group was significantly lower than thatin TPOAb–/TgAb– group (p &lt;0.05). At 3 yearspostpartum of the women with PPT, the rate of euthyroidism inTPOAb+/TgAb–, TPOAb–/TgAb+, andTPOAb+/TgAb+groups were significantly lower than that inTPOAb–/TgAb– group (p &lt;0.05). The values ofTPOAb and TgAb postpartum were significantly higher than those during pregnancy(p &lt;0.05). The incidence of PROM in TPOAb+/TgAb–group was significantly higher than that in TPOAb–/TgAb–group (32.99 vs. 17.72%, p &lt;0.05). The binary logisticregression for PPT showed that the OR value of TPOAb was 2.263 (95% CI1.142–4.483, p=0.019). The OR value of TgAb was 3.112(95% CI 1.700–5.697, p=0.000). In conclusion, pregnantwomen with positive thyroid auto-antibodies had an increased risk of PPT and areduced rate of euthyroidism at 2 and 3 years postpartum. TPOAb is associatedwith the incidence of PROM. Both of TPOAb and TgAb were independent risk factorsfor PPT. TgAb deserves more attention when studying autoimmune thyroid disease(AITD) combined with pregnancy.

Effects of Thyroperoxidase Antibody and Thyroglobulin Antibody on Maternal and Neonatal Outcomes in Pregnant Women