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The aim of the study was to establish the influence of glucocorticoids (GC) onfracture risk, probability, and prevalence. A set of 1548 postmenopausal womenwere divided into study group – treated with GC (n=114, age66.48±7.6 years) and controls (n=1434, age 66.46±6.83years). Data on clinical risk factors for osteoporosis and fractures werecollected. Hip bone densitometry was performed using a device Prodigy (GE, USA).Fracture probability was established by FRAX, and fracture risk by Garvanalgorithm and POL-RISK. Fracture risk and fracture probability weresignificantly greater for GC-treated women in comparison to controls. In thestudy group, there were 24, 3, 24, and 6 fractures noted at spine, hip, forearm,and arm, respectively. The respective numbers of fractures reported in controlsat those skeletal sites were: 186, 23, 240, and 25. The use of GCs increasedsignificantly prevalence of all major, spine and arm fractures. Also the numberof all fractures was affected by GC use. Following factors significantlyincreased fracture probability: age (OR 1.04 per each year; 95% CI:1.03–1.06), GC use (OR 1.54; 95% CI: 1.03–2.31), falls(OR 2.09; 95% CI: 1.60–2.73), and FN T-score (OR 0.62 per eachunit; 95% CI: 0.54–0.71). In conclusion, in patients treatedwith GCs the fracture risk, probability, and prevalence were increased. Thiseffect was evident regardless of whether GC therapy is included in the algorithmas a risk factor (FRAX, POL-RISK) or not taken into consideration (Garvannomogram).

hormone and metabolic research

Glucocorticoids Increase Fracture Risk and Fracture Prevalence Independently from Bone Mineral Density and Clinical Risk Factors: Results from the Gliwice Osteoporosis (GO) Study