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Objective Aluminum phosphide (AlP) is widely used to protect stored foodproducts and grains from pests and rodents. The availability of AlP, especiallyin Asian countries it has become a desirable factor to commit suicide. Thephosphine produced from ALP is a very reactive radical and a respiratoryinhibitor that causes oxidative damage. There is no dedicated antidote oreffective drug to manage AlP-induced lung toxicity. The present study aims toevaluate and compare the protective effects of curcumin and nanocurcumin onALP‑induced subacute lung injury and determine the underlying mechanism.  Methods Rats were exposed to AlP (2 mg/kg/day,orally)+curcumin or nanocurcumin (100 mg/kg/day,orally) for 7 days. Then rats were anesthetized and lung tissues were collected.Oxidative stress biomarkers, genes expression of antioxidant enzymes,participated genes in the SIRT1/FOXO3 pathway, and lung histopathologywere assessed by biochemical and ELISA methods, Real-Time PCR analysis, andH&amp;E staining.  Results Curcumin and nanocurcumin produced a remarkable improvement inAlP-induced lung damage through reduction of MDA, induction of antioxidantcapacity (TAC, TTG) and antioxidant enzymes (CAT, GPx), modulation ofhistopathological changes, and up-regulation of genes expression of SIRT1,FOXO3, FOXO1 in lung tissue.  Conclusion Nanocurcumin had a significantly more protective effect thancurcumin to prevent AlP-induced lung injury via inhibition of oxidative stress.Nanocurcumin could be considered a suitable therapeutic choice for AlPpoisoning.

drug research

Evaluation of Protective Effects of Curcumin and Nanocurcumin on Aluminium Phosphide‑Induced Subacute Lung Injury in Rats: Modulation of Oxidative Stress through SIRT1/FOXO3 Signalling Pathway