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The Pantanal wetland harbors a rich flora with uncharted pharmacologicalpotential. This study evaluated 20 Brazilian Pantanal plants against Candidaalbicans, C. parapsilosis, C. tropicalis, and C. krusei. Fungalsusceptibility was determined by agar diffusion and broth microdilution; activecompounds were identified by bioautography and HPLC-DAD-MS/MS.Sesbania virgata, Polygala molluginifolia, and Cantinoa mutabilisextracts and their chloroform and ethyl acetate (EtOAc) fractions exhibited thebest activity against all Candida species tested. The EtOAc fraction ofP. molluginifolia proved to be more efficient in inhibiting C.parapsilosis and C. krusei growth (Minimum inhibitoryconcentration of 125 and 62.5 μg/mL, respectively).Bioautography of this fraction revealed two active bands, characterized byHPLC-DAD-MS/MS as a mixture of podophyllotoxin derivatives blumenol,besides some flavonoids. This work demonstrated antifungal potential of P.molluginifolia podophyllotoxin derivatives and the versatility ofbioautography with HPLC-DAD-MS/MS to identify the bioactivecompounds.

Screening of 20 Pantanal Wetland Plants for Anti-Candida Activity using HPLC-DAD-MS/MS and Bioautography to Characterize Active Compounds