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A new flavone derivative named pachypodostyflavone (1), along with 8 knowncompounds (2–9) and a mixture of β-sitosterol andstigmasterol were isolated from the stem bark of Duguetia staudtii(Annonaceae), based on a bioassay-guided fractionation. Their structures weredetermined using high-resolution mass spectrometry and NMR spectroscopic data,as well as by comparison with the literature values of their analogs. Selectedisolated compounds were evaluated for their in vitro antifilaricidalactivities on Onchocerca ochengi microfilariae and adult worms.Inhibition of motility was evaluated spectroscopically on microfilaria and adultmale worms. Viability was determined on adult female worms by the MTT/Formazan assay. Auranofin at 10 µM and 2% DMSO were used aspositive and negative controls, respectively. Compounds 1 and 7showed potent anti-onchocerca activities with 100% activity at 250µg/mL on both O. ochengi adult male and female worms,while compound 5 displayed 100% activity at30 µg/mL.

Pachypodostyflavone, a New 3-methoxy Flavone and Other Constituents with Antifilarial Activities from the Stem Bark of Duguetia staudtii