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p-Cymene is a monoterpene found in over 100 plant species. It shows arange of biological activity, including anti-inflammatory and antimicrobialeffects. It is possibly a new therapeutic alternative for autism spectrumdisorder characterized by deficits in interaction and behavioral abnormalities.These symptoms can occur in response to maternal immune activation throughprenatal exposure to lipopolysaccharide. Thus, this study aimed to evaluate thebehavioral, memory, and biochemical effects of chronic administration ofp-cymene in an animal model of autism by prenatal maternal exposureto lipopolysaccharide. Twenty-four pregnant Wistar rats were used, who received100 μg/kg of lipopolysaccharide or saline intraperitoneally(i.p.) on the 9.5 gestational day. After birth, the male offspring remained withthe mothers until weaning and underwent model validation tests on postnatal day30. From postnatal day 31 on, chronic administration, via i.p., of saline (1mL/kg), risperidone (0.2 mg/kg), or p-cymene (100mg/kg) for 22 days was performed. The animals were submitted tobehavioral (postnatal day 52) and memory tests (postnatal days 52–53)and subsequently sacrificed (postnatal day 54) when their brain structures wereremoved for quantification of proinflammatory cytokines (TNF-α,interleukin 1β, and interleukin 6). Prenatal exposure tolipopolysaccharide significantly increased episodes of stereotyped movement(p=0.0001) and decreased parameters of social interaction in offspring,including sniffing, following, mounting, and allowing mounting(p=0.0043, p&lt;0.0001, p=0.0009, and p=0.0200,respectively). Chronic p-cymene treatment was not significant forbehavioral, memory, and biochemical tests. However, due to their pharmacokineticcharacteristics, p-cymene nanomaterials’ formulation may be anexciting alternative to be tested for further results.

Effects of Chronic Administration of P-Cymene in an Animal Model of LPS-Induced Autism