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The skin color is imparted by the pigment melanin produced in the melanosomes ofmelanocytes, through the catalytic action of melanogenesis enzymes tyrosinase,tyrosinase-related protein 1, and dopachrome tautomerase. Disruptions in themelanogenesis process may result to hypopigmentation, as observed in cutaneouspostinflammatory conditions. Here, the bioactivity of tara tannin, specificallyon melanogenesis, was evaluated in vitro using human epidermalmelanocytes (HEM) and B16F10 murine melanoma cells in order to determine thepossibility that it may be used as a treatment against hypopigmentation. Themelanin content of tara tannin-treated B16F10 cells and the expression level ofmelanogenesis enzymes and melanosome transport proteins were determined. Toelucidate the underlying mechanism of tara tannin’s effect onmelanogenesis, DNA microarray analysis was performed. Tara tannin significantlyincreased melanogenesis in both murine and human pigment cell models byupregulating melanogenesis-associated enzymes’ (tyrosinase,tyrosinase-related protein 1, and dopachrome tautomerase) protein and mRNAexpression levels, as well as the melanosome transport proteins (myosin Va andRAB27A) expression, both attributed to increased microphthalmia-associatedtranscription factor (MITF) expression. Global gene expression analysis resultsrevealed the modulation of genes (p≤0.05; fold-change ≥2.0 and≤−2.0) that are under the transcriptional regulation of MITF andgenes relevant for MAPK signaling, metabolic pathways, and cell cycle. Taratannin has a significant effective melanogenesis-promoting effect, making it apotential therapeutic agent against hypopigmentation disorders. This is thefirst report on the melanogenesis regulatory effect of tara tannin invitro.

Tara Tannin Regulates Pigmentation by Modulating Melanogenesis Enzymes and Melanosome Transport Proteins Expression