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During endoscopic submucosal dissection (ESD) of large esophageal lesions, adjunct strategies are needed to generate adequate tissue tension besides the traditional distal attachment cap [1, 2]. These tension-generating maneuvers are moderately effective, require additional devices [3], and can be time consuming. In this video, we demonstrate the successful use of a proximal “mucosal bridge technique” to efficiently and quickly complete ESD of a large squamous cell carcinoma (SCC) in the esophagus, obviating the need for supplementary traction devices (▶Video 1). A 74-year-old man underwent esophagogastroduodenoscopy and was found to have a large nodular and granular lesion in the middle of the esophagus (▶Fig. 1). Biopsies revealed SCC in situ and endoscopic ultrasound examination demonstrated that the lesion was limited to the mucosa. The decision was made to pursue en bloc resection via ESD. Chromoendoscopy with Lugol’s solution demonstrated an unstained area measuring 50mm in length and involving 90% of the esophageal circumference. Thermocautery marks were placed circumferentially using the retracted tip of a DualKnife (Olympus, Center Valley, Pennsylvania, USA) (▶Fig. 2). Initial mucosal incision was performed using the DualKnife at the distal aspect of the lesion after a submucosal lift was achieved by injecting methylene blue mixed with normal saline (Needle Master; Olympus). A nearly complete marginal mucosal incision was then made around the lesion using the IT nano knife (Olympus) while intentionally preserving an intact mucosal margin, 4mm wide, at the most proximal aspect of the lesion (▶Fig. 3). This “mucosal bridge” was left intact to provide traction during the submucosal dissection portion of the ESD. With the mucosal bridge acting as an anchor, entry into the dissection plane was readily accomplished and submucosal dissection was then easily carried out using the IT nano knife in the cephalocaudal direction. Upon completion of E-Videos

Endoscopic submucosal dissection of a large squamous cell cancer using the proximal mucosal bridge technique