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A 61-year-old man was referred to our institute for endoscopic ultrasound (EUS) evaluation of a subcentimeter subepithelial lesion of the duodenal bulb. Ultrasound imaging showed a homogeneous, hypoechoic lesion of 15mm in diameter in the fourth layer of the inferior wall of the duodenal bulb (▶Fig. 1 a, b). EUSguided fine needle aspiration showed a gastrointestinal stromal tumor (GIST) and a computed tomography scan confirmed only a localized lesion (▶Fig. 1 c). The growth in size of the GIST with respect to the previous examination was an indication for resection, which remains the only modality that can offer permanent cure of GISTs, and avoid tumor rupture and injuries to the pseudocapsule [1]. Given the wishes of the patient and in order to avoid major surgery, a multidisciplinary team (endoscopist, oncologist, and surgeon) proposed an endoscopic mini-invasive approach. The procedure was performed with the patient under general anesthesia and with the administration of prophylactic antibiotics. Dissection was performed using an O-type HybridKnife (Erbe Elektromedizin, Germany) and we infused only saline solution into the lumen in order to prevent retroperitoneal CO2 leakage and the consequent subcutaneous emphysema. We performed a full-thickness resection with the aim of achieving a radical oncological resection (▶Video1). The excision resulted in a complete duodenal wall defect, about 25×25mm (▶Fig. 2), which was closed with three endosutures placed using the OverStitch endoscopic suturing system (Apollo Endosurgery, USA). In the post-procedural phase, the patient developed pain in the hypochondrium that was easily controlled with a single dose of ibuprofen; oral intake was restarted in the fourth postoperative day. In the following 2 months of follow-up, the patient remained asymptomatic. E-Videos

Underwater full-thickness resection of a duodenal bulb gastrointestinal stromal tumor with OverStitch defect repair