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A 45-year-old man was referred to our surgery department for treatment of an ileal polyp detected in a previous colonoscopy, after a positive fecal immunochemical test. The colonoscopy showed a 40-mm pedunculated polyp, with ulcers, in the distal ileum (▶Fig. 1 a). A magnifying endoscopy with narrowband imaging showed no capillary vessels, which suggested that a non-neoplastic epithelium covered a subepithelial lesion (▶Fig. 1b). The pathological examination of biopsies showed only inflammatory etiology and we could not reach a definitive diagnosis. An endoscopic resection was initiated for histological evaluation. We performed a clip-assisted snare polypectomy and achieved en bloc removal, with no adverse events (▶Fig. 2 a, ▶Video1). Gross examination showed a 40-mm polyp with ulceration (▶Fig. 2b). Pathological examination showed fibroblast proliferation and vessels infiltrated with inflammatory cells, including eosinophils (▶Fig. 2 c). The diagnosis was inflammatory fibroid polyp (IFP). IFPs are benign submucosal lesions. The endoscopic features of small-bowel IFPs are not well recognized, because most reported cases undergo surgery with no endoscopic attempts owing to the presence of urgent symptoms, such as intussusception, obstruction, or bleeding [1]. In the current case, the ileal polyp was asymptomatic and was detected by colonoscopy. In addition, we could observe pedunculated morphology, patchy ulceration, and a non-neoplastic epithelium covering (subepithelial polyp). Our case is, to the best of our knowledge, the largest small-bowel IFP treated by endoscopy based on preoperative diagnosis; previously reported cases measured 20–30mm in diameter [1–4]. By clipping the stalk of the polyp to prevent postpolypectomy bleeding [5], we could remove the huge polyp with no complications. In such asymptomatic cases, endoscopic removal for apparently benign ileal subepithelial polyps could not only provide histological clues for treatment but also avoid surgery. E-Videos

A huge inflammatory fibroid polyp: an unexpected finding after positive fecal immunochemical test