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A 69-year-old patient with massive hematemesis was transferred to our intensive care unit. Additional clinical symptoms were melena, fatigue, and severe anemia with an initial hemoglobin level of 6.9 g/dL. The patient’s medical history was uneventful and without significant comorbidity. Previous endoscopic examinations performed elsewhere had revealed an angiodysplastic lesion in the gastric fundus, as well as two non-bleeding angiodysplastic lesions in the cecum, which had been treated with argon plasma coagulation (APC) and hemoclip application. Unfortunately, the patient’s physical condition progressively worsened, with severe gastrointestinal (GI) bleeding, tachycardia, and hypotension despite endoscopic intervention and the transfusion of numerous units of red blood cells (n =12) and fresh frozen plasma (FFP) over the next 72 hours. The clinical course was additionally complicated by aspiration-induced pneumonia and antibiotic treatment was required (ceftriaxone 2g once daily and metronidazole 500mg three times per day). Because further episodes of significant hematemesis occurred repeatedly and gastroscopy failed to identify the bleeding source, we decided to intensify the diagnostic approach and performed an upper GI single-balloon enteroscopy (SIF-Q180; Olympus), which identified a Dieulafoy-like pulsating lesion in the distal jejunum (▶Fig. 1). The lesion was marked with two hemoclips and definitive hemostasis was achieved following application of an over-the-scope clip (OTSC; Ovesco, Tübingen, Germany). For this purpose, the 14/6 t OTSC clip was mounted on a colonoscope (CF-H165L; Olympus) and successfully released at the marked site of bleeding in the distal jejunum (▶Video1). Video 1 Colonoscopy-assisted placement of a 14/6 t over-the-scope clip to treat a bleeding Dieulafoy lesion in the distal jejunum, with follow-up after 6 days showing ongoing hemostasis. ▶ Fig. 1 Image during single-balloon enteroscopy showing a pulsating Dieulafoy lesion in the distal jejunum. E-Videos

Colonoscopy-assisted application of a 14/6t over-the-scope clip for treatment of a bleeding Dieulafoy lesion in the distal jejunum