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Methods of closing mucosal defects after gastric endoscopic submucosal dissection (ESD) have been reported [1–3]. However, closing large mucosal defects in the stomach is considered difficult compared with other parts of the intestinal tract because the submucosal layer is thick [4]. We designed the threadassisted closure method using a lockingclip technique (LCT) for closing mucosal defects. Thread-assisted closure using LCT uses clips and a thread (commercially available dental floss). After setting the clip, the thread is fixed on the proximal side of the clip’s tooth (▶Fig. 1). LCT involves the clip and thread becoming strongly fixed when fully opened. First, a threaded clip is attached to the marginal defect edge followed by the mucosal defect margin on the contralateral side. Next, LCT is performed by pulling the thread and bringing the mucosal defect margins close to each other (▶Video1). The mucosal defect margins are fixed, and the defect base is completely closed by repeating the technique. We closed a mucosal defect of approximately 50mm in size after gastric ESD using thread-assisted closure via LCT. First, the endoscope was pulled out from the stomach, a clip fixed with the thread was attached, and the scope was reinserted. The first clip was attached to the marginal part of the defect on the anal side. Subsequently the second clip was attached to the mucosal defect margin. Finally, LCT was used to completely fix the margins (▶Fig. 2,▶Video1). Repeated LCT helped perform thread-assisted closure multiple times to completely close the defect. The patient was discharged uneventfully. Thread-assisted closure and line-assisted complete closure are effective methods for closing mucosal defects. By using LCT, it was possible to perform threadassisted closure several times with a single thread and bring rigid mucosal defect margins together. Thread-assisted closure using LCT is a safe and effective mucosal defect closure method. Endoscopy_UCTN_Code_TTT_1AO_2AG E-Videos

Thread-assisted mucosal defect closure using the locking-clip technique after gastric endoscopic submucosal dissection