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Rheumatoid arthritis (RA) is an autoimmune disease thataffects multiple joints causing joint destruction. KIAA1199 is a novelangiogenic biomarker derived from fibroblast-like synoviocytes (FLS) it has arole in acceleration and proliferation of FLS and activation of angiogenicsignaling pathways leading to erosion of cartilage and bone. Musculoskeletalultrasound (MUSU) and Power Doppler (PDUS) directly visualizing the synovialmembrane vessels, which is important in providing very early information on thechanges in synovitis activity during the course of the inflammatory jointdisease  Objective To assess the serum level of angiogenic biomarker KIAA1199 inRA patients and its correlation with MSUS, PDUS findings, and the diseaseactivity Patients and methods: Fifty RA patients and 40 healthy control personsage and sex-matched were recruited in this study, KIAA1199 was assessed in theserum of patients and controls, MSUS and PDUS were done for the wrist, elbow,and knee joints for all RA patients  Results Serum KIAA1199 level was significantly higher among RA patients4.36±1.22 ng/dl compared to control group2.87±0.51 ng/dl (p&lt;0.001). There was a highlysignificant correlation between KIAA1199 level and DAS28 (p=0.004), andthere was a significant correlation between the PDUS with KIAA1199 level andDAS28 (p=0.001, 0.002 respectively) in wrist joints  Conclusion KIAA1199 is a new pathway that enhancing cell proliferationand angiogenesis. Serum KIAA1199 level may be a useful biomarker for RAactivity, and therapeutic target in RA. PDUS correlates significantly withclinical findings and novel angiogenic biomarker in RA patients.

KIAA1199 Biomarker and Ultrasonographic Findings in Rheumatoid Arthritis Patients and their Correlation with Disease Activity