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Gastropulmonary fistulas following transthoracic en bloc esophagectomy and intrathoracic gastric reconstruction (Ivor Lewis esophagectomy) are rare but life-threatening complications. Surgical management of these is difficult and associated with significant instances of morbidity andmortality [1]. One possible treatment for leaks after upper gastrointestinal surgery is endoluminal vacuum therapy (EVT) [2]. A newer treatment option is the endoscopic suturing system Apollo Overstitch [3–5]. The Overstitch is a single-use device that is placed on top of a double-channel therapeutic endoscope, which facilitates full-thickness surgical suturing in single or running technique. To our knowledge, the case presented below constitutes the first successful clinical application of a combination of Overstitch and EVT to close a gastropulmonary fistula after Ivor Lewis esophagectomy. We present the case of a 58-year-old man who underwent neoadjuvant chemoradiation (CROSS protocol) followed by Ivor Lewis esophagectomy for esophageal adenocarcinoma (histopathology: ypT3, ypN2 (3/45), L1, V0, Pn0, R0). About 3 months after the initial surgery, the patient was admitted to our hospital with recurring episodes of pneumonia. Computed tomography (CT) scanning with oral contrast and endoscopy showed a fistula between the pull-up gastric interponate and the right lung parenchyma (▶Fig. 1 and ▶Fig. 2). We applied the Overstitch system to close the fistula endoscopically. After two attempts, we were able to close the fistula using the single-suturing technique (▶Fig. 3; ▶Video1). A triple-lumen diverted nasal tube (e. g. Freka Trelumina; Fresenius Kabi, Germany) was then inserted to allow the patient to receive enteral feeding. Furthermore, to evacuate any biliary reflux and to reduce the pressure on the suturing line, we placed a polyurethane foam drainage tube (e. g. EsoSponge; Braun, Germany) with negative pressure (–125mmHg, continuous; VivanoTec; Hartmann AG, Germany). During the 31 days of this EVT, the foam drainage was changed seven times. E-Videos

Successful closure of a gastropulmonary fistula after esophagectomy using the Apollo Overstitch and endoscopic vacuum therapy