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are specifically radioimmunoassayed, and urinary androgens determined by gas chromatography. Spermatogenesis is determined using spermocytograms or by testis biopsy ; LHRH and TRH tests are used. In the second part of the study, 18 infertile men having high prolactin levels are treated with bromocriptine for one month (5 mg/day), and the above tests repeated during the treatment. Using spermograms and the LH-RH test, the patients are divided into the following groups : control (1), normogonadotropics (2), hypogonadotropics with lower titers of LH and/or FSH (3), hypergonadotropics with LH (and sometimes FSH) response to LH-RH greater than normal with normal or slightly higher basic levels (4), azoopermia with no spermatogenesis (5). Prolactin secretion and correlation with gonadotropins and androgens. Prolactin secretion is higher before or after TRH in 40 p. 100 of infertile men. There seems to be a correlation between gonadotropins and prolactin ; this result provides additional evidence that there is no antagonism between prolactin and gonadotropin secretion in man. Prolactin secretion is frequently correlated with plasma testosterone or urinary androgens. However, this correlation is negative when spermatogenesis is blocked before the spermatocyte stage. Results obtained during treatment with bromocriptine. Prolactin secretion, basal levels ai,d response to TRH are reduced. At the same time, basic FSH and LH increase and androgens decrease, but these modifications are slight and the range of individual variation is wide. The number of spermatozoa also increases considerably (15 to 31 x 10 6/ml). This result suggests that hyperprolactinemia interfers with the final stages of spermatogenesis and that bromocriptine treatment leads to resumption of normal gonadic function.

Prolactin secretion in infertile men before and after treatment with bromocriptine