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The aim of the work was to study the level of somatic gene mutagenesis in various human contingents exposed to ionizing radiation at doses up to 200 mSv. Flow cytometry was used to determine frequency of variant CD4+ T-lymphocytes with altered T-cell receptor (TCR) /CD3 expression as result of mutations at TCR locus. The TCR-mutant cell frequency was assessed in 250 unexposed control donors and 1198 exposed persons, including employees of Nuclear Power Engineering (mean dose (±SE) 100,0±6,6 MSv was accumulated within 27,4±1,1 years), cleanup workers of the Chernobyl accident (mean dose 100,0±9,1 MGy, analysis was performed 9-19 years after the irradiation) and persons living in radiation contaminated areas (137 Cs density 37- 555 kBq/m2 ) during 15-19 years. Results of group analysis demonstrated an increase in frequency of the TCR-mutant cells in NPE employees and the Chernobyl cleanup workers compared to that in age-matched control groups (p Cs density over 100 kBq/m2 in comparison to less contaminated areas: 14,5% vs 8,8% accordingly (p=0,02, Fishers test). In conclusion, relatively small proportion of persons was found to react to low dose radiation exposure by elevation of the TCR-mutant cell frequency in all groups excluding irradiation in utero. The work was supported by Russian Foundation of Basic Research (# 08-04-00790).

Individual Response to Low Dose Radiation Exposure as Determined by TCR Assay