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The genus  Eimeria  (Apicomplexa, Coccidia) provides a wide range of different species with different hosts to study common and variable features within the genus and its species. A common characteristic of all known  Eimeria  species is the oocyst, the infectious stage where its life cycle starts and ends. In our study, we utilized  Eimeria nieschulzi  as a model organism. This rat-specific parasite has complex oocyst morphology and can be transfected and even cultivated  in vitro  up to the oocyst stage. We wanted to elucidate how the known oocyst wall-forming proteins are preserved in this rodent  Eimeria  species compared to other  Eimeria . In newly obtained genomics data, we were able to identify different gametocyte genes that are orthologous to already known  gam  genes involved in the oocyst wall formation of avian  Eimeria  species. These genes appeared putatively as single exon genes, but cDNA analysis showed alternative splicing events in the transcripts. The analysis of the translated sequence revealed different conserved motifs but also dissimilar regions in GAM proteins, as well as polymorphic regions. The occurrence of an underrepresented  gam56  gene version suggests the existence of a second distinct  E. nieschulzi  genotype within the  E. nieschulzi  Landers isolate that we maintain.

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Identification and analysis ofEimeria nieschulzigametocyte genes reveal splicing events ofgamgenes and conserved motifs in the wall-forming proteins within the genusEimeria(Coccidia, Apicomplexa)