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Primary amoebic meningoencephalitis (PAM) is a fatal infection in most cases, caused by the amoeba flagellate  Naegleria fowleri . This report describes the first cases of PAM in Algeria, in a cow and a ewe from Batna, north-eastern Algeria. The death of both ruminants occurred a week after the first clinical manifestations. The cerebrospinal fluid, after staining with May-Grünwald-Giemsa, showed the presence of amoebae cells. Histological sections revealed numerous amoebae in all parts of the brain. The presence of  N. fowleri  was confirmed using a species-specific real-time PCR in histological tissue sections. The two PAM cases were reported during the hot season, and the source of infection is very likely the water where the cattle came to drink. Particular attention should be focused on this type of infection in aquatic environments when the temperature is high and preventive measures must be taken to avoid the proliferation of  N .  fowleri .

Meningoencephalitis due to the amoeboflagellateNaegleria fowleriin ruminants in Algeria