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Recently,  Dientamoeba fragilis  has emerged as a significant and common enteropathogen. The majority of patients with dientamoebiasis present with gastrointestinal complaints and chronic symptoms are common. Numerous studies have successfully demonstrated parasite clearance, coupled with complete resolution of clinical symptoms following treatment with various antiparasitic compounds. Despite this, there is very little  in vitro  susceptibility data available for the organism. Benzimidazoles are a class of antiparasitic drugs that are commonly used for the treatment of protozoan and helminthic infections. Susceptibility testing was undertaken on four  D. fragilis  clinical isolates against the following benzimidazoles: albendazole, flubendazole, mebendazole, nocodazole, triclabendazole and thiabendazole. The activities of the antiprotozoal compounds at concentrations ranging from 2 μg/mL to 500 μg/mL were determined via cell counts of  D. fragilis  grown in xenic culture. All tested drugs showed no efficacy. The beta-tubulin transcript was sequenced from two of the  D. fragilis  isolates and amino acid sequences predicted a susceptibility to benzimidazoles. This is the first study to report susceptibility profiles for benzimidazoles against  D. fragilis , all of which were not active against the organism. This study also found that beta-tubulin sequences cannot be used as a reliable marker for resistance of benzimidazoles in  D. fragilis .

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Activity of benzimidazoles against<i>Dientamoeba fragilis</i>(Trichomonadida, Monocercomonadidae)<i>in vitro</i>and correlation of beta-tubulin sequences as an indicator of resistance

Activity of benzimidazoles againstDientamoeba fragilis(Trichomonadida, Monocercomonadidae)in vitroand correlation of beta-tubulin sequences as an indicator of resistance