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Leishmaniasis is a vector-borne disease caused by protozoan parasites of the genus  Leishmania . Our knowledge of protein phosphatases (PPs) and their implication in signaling events is very limited. Here we report the expression, characterization and mutagenesis analysis of a novel protein phosphatase 5 (PP5) in  Leishmania major . Recombinant PP5 is a  bona fide  phosphatase and is enzymatically active. Site-directed mutagenesis revealed auto-inhibitory roles of the N-terminal region. This is a rational first approach to understand the role of PP5 in the biology of the parasite better as well as its potential future applicability to anti-parasitic intervention.

Catalytic activity of a novel serine/threonine protein phosphatase PP5 fromLeishmania major