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Plasmodium falciparum  erythrocyte membrane protein 1 (PfEMP1) is an important virulence factor encoded by a family of 59  var  genes, including 56  var  genes plus 3 small  var3  genes. The  var  genes are among the most diverse sequences in the  P. falciparum  genome, but the  var3  genes are found conserved in most  P. falciparum  strains. Previous studies have been mainly focused on the typical  var  genes, while the biological characteristics of the  var3  genes remain unknown. In this study, the three  var3  genes, PF3D7_0100300, PF3D7_0600400, and PF3D7_0937600, were found to be transcribed in the erythrocytic stages of  P. falciparum , with a peak in the transcription level at 16 h post-invasion, but terminated immediately after 16 h post-invasion. The encoded protein of PF3D7_0600400 could be detected in both the late trophozoite stage and schizont stage, while the encoded proteins of PF3D7_0100300 and PF3D7_0937600 could only be detected in the late trophozoite stage and schizont stage, respectively. Thus, the  var3  genes of the  P. falciparum  3D7 strain were differentially expressed during the erythrocytic development of the parasite.

Thevar3genes ofPlasmodium falciparum3D7 strain are differentially expressed in infected erythrocytes