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We study the propagation of nucleons and nuclei in tissue-like media within aMonte Carlo Model for Heavy-ion Therapy (MCHIT) based on the GEANT4 toolkit(version 8.2). The model takes into account fragmentation of projectile nucleiand secondary interactions of produced nuclear fragments. Model predictions arevalidated with available experimental data obtained for water and PMMA phantomsirradiated by monoenergetic carbon-ion beams. The MCHIT model describes well(1) the depth-dose distributions in water and PMMA, (2) the doses measured forfragments of certain charge, (3) the distributions of positron emitting nuclearfragments produced by carbon-ion beams, and (4) the energy spectra of secondaryneutrons measured at different angles to the beam direction. Radial doseprofiles for primary nuclei and for different projectile fragments arecalculated and discussed as possible input for evaluation of biological dosedistributions. It is shown that at the periphery of the transverse dose profileclose to the Bragg peak the dose from secondary nuclear fragments is comparableto the dose from primary nuclei.

MCHIT - Monte Carlo model for proton and heavy-ion therapy