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In this forum, we develop the idea that the human genome may not be equipped to protect us after the age of reproduction against certain diseases such as cancer or neuro-degenerative diseases. We take as example cancer and show that adding one tumor suppressor in the mouse genome in its genomic context (BAC transgene) provides some protection against spontaneous and induced tumors. We also show that in certain species displaying a resistance to cancer, there is an amplification of some tumor suppressor genes.

Pourquoi n’avoir que deux copies du gèneP53?