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323 m/s n° 4, vol. 32, avril 2016 DOI : 10.1051/medsci/20163204004 resistance to influenza virus. J Biol Chem 2012 ; 287 : 19631-41. 9. Chesarino NM, McMichael TM, Yount JS. E3 ubiquitin ligase NEDD4 promotes influenza virus infection by decreasing levels of the antiviral protein IFITM3. PLoS Pathog 2015 ; 11 : e1005095. 10. Chesarino NM, McMichael TM, Hach JC, Yount JS. Phosphorylation of the antiviral protein IFITM3 dually regulates its endocytosis and ubiquitination. J Biol Chem 2014 ; 289 : 11986-92. 11. Malakhova OA, Zhang DE. ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response. J Biol Chem 2008 ; 283 : 8783-7. 5. Tartour K, Appourchaux R, Gaillard J, et al. IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity. Retrovirology 2014 ; 11 : 103. 6. Compton AA, Bruel T, Porrot F, et al. IFITM proteins incorporated into HIV-1 virions impair viral fusion and spread. Cell Host Microbe 2014 ; 16 : 736-47. 7. Jia R, Pan Q, Ding S, et al. The N-terminal region of IFITM3 modulates its antiviral activity by regulating IFITM3 cellular localization. J Virol 2012 ; 86 : 13697-707. 8. Yount JS, Karssemeijer RA, Hang HC. S-palmitoylation and ubiquitination differentially regulate interferoninduced transmembrane protein 3 (IFITM3)-mediated RÉFÉRENCES

Coopération entre mutation somatique et variant génétique de susceptibilité dans le sarcome d’Ewing