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943 m/s n° 11, vol. 30, novembre 2014 DOI : 10.1051/medsci/20143011004 10. de la Mata M, Alonso CR, Kadener S, et al. A slow RNA polymerase II affects alternative splicing in vivo. Mol Cell 2003 ; 12 : 525-32. 11. Dutertre M, Sanchez G, De Cian MC, et al. Cotranscriptional exon skipping in the genotoxic stress response. Nat Struct Mol Biol 2010 ; 17 : 1358-66. 12. Dujardin G, Lafaille C, de la Mata M, et al. How slow RNA polymerase II elongation favors alternative exon skipping. Mol Cell 2014 ; 54 : 683-90. 7. Cramer P, Pesce CG, Baralle FE, Kornblihtt AR. Functional association between promoter structure and transcript alternative splicing. Proc Natl Acad Sci USA 1997 ; 94 : 11456-60. 8. Kornblihtt AR, Schor IE, Allo M, et al. Alternative splicing: a pivotal step between eukaryotic transcription and translation. Nat Rev Mol Cell Biol 2013 ; 14 : 153-65. 9. de la Mata M, Kornblihtt AR. RNA polymerase II C-terminal domain mediates regulation of alternative splicing by SRp20. Nat Struct Mol Biol 2006 ; 13 : 973-80. RÉFÉRENCES

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