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m/s n° 6-7, vol. 28, juin-juillet 2012 DOI : 10.1051/medsci/2012286009 9. Lacolley P, Regnault V, Nicoletti A, et al. The vascular smooth muscle cell in arterial pathol ogy: a cell that can take on multiple roles. Cardiovasc Res 2012 (sous-presse). 10. Ait-Oufella H, Salomon BL, Potteaux S, et al. Natural regulatory T cells control the development of atherosclerosis in mice. Nat Med 2006 ; 12 : 178-80. 1 1. Caligiuri G, Nicoletti A, Poirier B, Hansson GK. Protective immunity against atherosclerosis carried by B cells of hypercholesterolemic mice. J Clin Invest 2002 ; 109 : 745-5 3. 12. Ho-Tin-Noé B, Le Dall J, Gomez D, et al. Early atheroma-derived agonists of peroxisome proliferator-activated receptor- trigger intramedial angiogenes is in a smooth muscle cell-dependent manner. Circ Res 2011 ; 109 : 1003-14. 13. Le Dall J, Ho-Tin-Noé B, Louedec L, et al. Immaturity of microvessels in haemorrhagic plaques is associated with proteolytic degradation of angiogenic factors. Cardiovasc Res 2010 ; 85 : 184-93. 14. Tréguer K, Heydt S, Hergenreider E. Protection des vaisseaux sanguins contre l’athérosclérose : le rôle des miARN sécrétés par l’endothélium. Med Sci (Paris) 2012 ; 28 : 584-7. 3. Duewell P, Kono H, Rayner KJ, et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholest erol crystals. Nature 2010 ; 464 : 1357-61. 4. Ridker PM, Thuren T, Zalewski A, Libby P. Interleukin-1 beta inhibition and the prevention of recurrent cardiovascular events: rationale and design of the Canakinumab anti-i nflammatory thrombosis outcomes study (CANTOS). Am Heart J 2011 ; 162 : 597-605. 5. Mertens M, Singh JA. Anakinra for rheumatoid arthritis: a systematic review . J Rheumatol 2009 ; 36 : 1118-25. 6. Lawrie A, Hameed AG, Chamberlain J, et al. Paigen diet-fed apolipoprotein E knockout mice develop severe pulmonary hypertension in an interleukin-1dependent manner. Am J Pathol 2011 ; 179 : 1693-705. 7. Saxena A, Rauch U, Berg KE, et al. The vascular repair process after injury of the carotid artery is regulated by IL-1RI and MyD 88 signalling. Cardiovasc Res 2011 ; 91 : 350-7. 8. Alexander MR, Moehle CW, Johnson JL, et al. Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vesse l remodeling in advanced atherosclerosis in mice. J Clin Invest 2012 ; 122 : 70-9. quels phénomènes parmi ceux-ci et de quelles fonctions sont-ils dotés ? Le progrès médical ne peut se suffire de telles approximations, surtout, lorsque des essais thérapeutiques incluant la participation humaine sont en jeu. ◊ Should we block interleukin-1 in atherothrombosis?

L’astrocyte, un partenaire clé des neurones au cours de la transmission synaptique de base