English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

In eukaryotic cell, a few meters of DNA are compacted in nuclear compartment of a few microns. This high level of compaction is an important way to regulate gene expression. In the present paper, we present a description of the organization of DNA into its first level of compaction: the nucleosome core particle. The structure of the nucleosome has been described at an atomic resolution more than 10 years ago, where DNA is wrapped around an octamer of histones. Post-translational modifications affecting histone tails have been shown to regulate the chromatin degree of compaction and thus the gene expression and regulation. The structure of the NCP is far from being frozen and is highly dynamic. Remodeling factors can induce DNA sliding around the histones, DNA transaction processes such as transcription and replication.

Structure et dynamique de la particule cœur de nucléosome