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The key role of NEMO, the regulatory subunit of IKK, in the NF-kB activation process is firmly established. A series of recent publications suggests that this protein also participates in the genotoxic response, after modification by sumoylation in the nucleus, and coordinates the activation of both NF-kB and IRFs during viral infection, through its interaction with TANK adaptor and TBK1/IKKepsilon kinases.

Les nouvelles fonctions de NEMO, la sous-unité régulatrice de la kinase activant NF-κB