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395 M/S n° 4, vol. 18, avril 2002 1. Vousden KH. p53: death star. Cell 2000 ; 103 : 691-4. 2. Tyner SD, Venkatachalam S, Choi J, et al. p53 mutant mice that display early ageing-associated phenotypes. Nature 2002 ; 415 : 45-3. 3. Homère. L'Odyssée. Chant XII. 4. Ferbeyre G, Lowe SW. The price of tumour suppression? Nature 2002 ; 415 : 26-7. 5. Williams GC. Pleiotropy, natural selection and the evolution of senescence. Evolution 1957 ; 11 : 398-411 6. Guarente L, Kenyon C. Genetic pathways that regulate ageing in model organisms. Nature 2000 ; 408 : 255-62 7. Tissenbaum HA, Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 2001 ; 410 : 227-30. 8. Luo J, Nikolaev AY, Imai S, et al. Negative control of p53 by Sir2a promotes cell survival under stress. Cell 2001 ; 107 : 137-48. 9. Vaziri H, Dessain SK, Ng Eaton E, et al. hSIR2(SIRT1) functions as an NADdependent p53 deacetylase. Cell 2001 ; 107 : 149-59. 10. Derry WB, Putzke AP, Rothman JH. Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance. Science 2001 ; 294 : 591-5. 11. Migliaccio E, Giorgio M, Mele S, et al. The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature 1999 ; 402 : 309-13. 12. Ameisen JC. Le jeu de la vie avec la mort. Le suicide cellulaire joue-t-il un rôle dans le vieillissement des corps ? La Recherche, Dossier Hors série « Le Temps », Avril 2001 ; 5 : 76-9.

Polymorphisme du gène codant pour le transporteur de la sérotonine et hypertension artérielle pulmonaire