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Neural correlate of major depressive disorder (MDD) and control of addition under emotional stimulus is still unclear. Addition under positive emotional stimulus (AP) and addition under negative emotional stimulus (AN) are two typical different cognitive processing, and with a common core component of rule induction. Previous studies have demonstrated that different processing is adopted in AP and AN completion tasks; even the underlying rules are identical. In the present study, we examined cortical activation as a function of two different machining processing for solving addition calculation under different emotional completion tasks. In AP completion tasks, involves direct retrieving of arithmetic knowledge to get the relations between items. In AN completion tasks, requires counting a certain number of times to detect the relations linking two items. The two processes require essentially the equivalent cognitive processes, but they have different working memory demands. In AN completion tasks produced significant greater activity involved in memory retrieval (dorsolateral prefrontal cortex, DLPFC) and mental representation/maintenance (posterior parietal cortex, PPC). An ACT-R model of the tasks successfully predicted the behavioral performance and BOLD response. The present findings positive emotional stimulus has promoting effect on addition cognitive calculate. Negative emotional stimulus has inhibiting effect on addition cognitive calculate

ACT-R Model for Addition Under Emotional Stimulus of Major Depressive Disorder and Control