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The cause(s) of Menière's disease is(are) not known but two main hypotheses have been proposed and have been widely accepted, to explain the characteristic symptoms : low frequency hearing loss, tinnitus and vertigo. It is supposed that there is an overpressure within the endolymphatic spaces accompanied by fissures in the membranes, and in particular in the Reissner's membrane, which leads to the mixing of potassium rich endolymph with perilymph. Our data do not fit well with such hypotheses and we have proposed a different mechanism. According to our hypothesis the swelling volume of endolymph displaces the Reissner's membrane towards scala vestibuli (SV) [which has a K+ concentration of 6.4 mM] which forces the outflow of perilymph through the helicotrema into scala tympani (ST) [which has a K+ concentration of 3.4 mM]. The relative doubling of the concentration of K within the ST towards the apex of the cochlea might provoke low frequency sensitivity loss, tinnitus, and cause a local deterioration of sensory hair cells and spiral ganglion cells

SYMPTOMS OF EXPERIMENTAL ENDOLYMPHATIC HYDROPS : POSSIBLY A POTASSIUM CONTAMINATION FROM PERILYMPH