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We present our recent results of baryon interactions with strangeness $S=-1$based on Nambu-Bethe-Salpeter (NBS) correlation functions calculated fromlattice QCD with almost physical quark masses corresponding to$(m_\pi,m_K)\approx(146,525)$ MeV and large volume $(La)^4=(96a)^4\approx$ (8.1fm)$^4$. In order to perform a comprehensive study of baryon interactions, alarge number of NBS correlation functions from NN to $\Xi\Xi$ are calculatedsimultaneously by using large scale computer resources. In this contribution,we focus on the strangeness $S=-1$ channels of the hyperon interactions bymeans of HAL QCD method. Four sets of three potentials (the $^3S_1-^3D_1$central, $^3S_1-^3D_1$ tensor, and the $^1S_0$ central potentials) arepresented for the $\Sigma N - \Sigma N$ (the isospin $I=3/2$) diagonal, the$\Lambda N - \Lambda N$ diagonal, the $\Lambda N \rightarrow \Sigma N$transition, and the $\Sigma N - \Sigma N$ ($I=1/2$) diagonal interactions.Scattering phase shifts for $\Sigma N$ $(I=3/2)$ system are presented.

Baryon interactions from lattice QCD with physical masses --- strangeness $S=-1$ sector ---